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| c. 10 BC |
| | The period of stability achieved during the reign of Augustus Caesar has been given the name Pax Romana ('Roman peace') | |
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| 4 |
| | After the death of two of his grandsons, the emperor Augustus formally adopts his stepson Tiberius as his successor | |
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| 4 |
| | Augustus Caesar insists on Tiberius adopting as his successor Germanicus, a talented young member of the imperial family | |
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| 5 |
| | Germanicus, designated eventual heir to the throne, marries Agrippina, granddaughter of the ruling emperor | |
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| 14 |
| | The death of Augustus introduces half a century of chaos, as the members of his family compete ruthlessly for power | |
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| 14 |
| | Tiberius succeeds his stepfather Augustus Caesar as the Roman emperor | |
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| 19 |
| | Germanicus, nephew and heir of the emperor Tiberius, dies when far away with the army in Syria | |
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| 37 |
| | Within the tangled and tormented web of the Roman imperial family, Gaius Caesar - nicknamed Caligula - inherits the throne | |
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| 41 |
| | Claudius, after the assassination of his nephew Caligula, is selected as emperor by the praetorian guards | |
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| c. 50 |
| | The Roman surgeon Cornelius Celsus describes in De Medicina how to cut stones from a patient's bladder | |
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